@theonefreeman not a Screenreader user myself, but I've supported a few in recent times
both Gnome and KDE have pretty thorough AT-SPI support for the DE itself. Xfce has been working toward it, and may be worth a try. The challenge will be apps; the accessibility model works great for apps that make accessibility system interaction investments, but rough otherwise
@theonefreeman in that case Firefox is generally adequate for AT-SPI, though last experiments had some weakness around text selection and some parts of image support (though alt text worked fine). Not as good as eg Safari, but likely to be acceptable.
Of course the question will be whether AT-SPI support for the particular assistive device exists; that's something I didn't have to worry about (devices selected for purpose in my case), but your friend might
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